Ventral tegmental area GABA neurons and opiate motivation
نویسندگان
چکیده
منابع مشابه
Ventral Tegmental Area GABA Neurons Are Resistant to GABA(A) Receptor-Mediated Inhibition During Ethanol Withdrawal
The neural mechanisms underlying alcohol dependence are not well-understood. GABAergic neurons in the ventral tegmental area (VTA) are a relevant target for ethanol. They are inhibited by ethanol at physiologically-relevant levels in vivo and display marked hyperexcitability during withdrawal. In the present study, we examined the effects of the GABA(A) receptor agonist muscimol on VTA neurons ...
متن کاملOpiate-induced molecular and cellular plasticity of ventral tegmental area and locus coeruleus catecholamine neurons.
The study of neuronal adaptations induced by opiate drugs is particularly relevant today given their widespread prescription and nonprescription use. Although much is known about the acute actions of such drugs on the nervous system, a great deal of work remains to fully understand their chronic effects. Here, we focus on longer-lasting adaptations that occur in two catecholaminergic brain regi...
متن کاملNeurotensin inhibits both dopamine- and GABA-mediated inhibition of ventral tegmental area dopamine neurons.
Dopamine is an essential neurotransmitter that plays an important role in a number of different physiological processes and disorders. There is substantial evidence that the neuropeptide neurotensin interacts with the mesolimbic dopamine system and can regulate dopamine neuron activity. In these studies we have used whole cell patch-clamp electrophysiology in brain slices from mice to examine h...
متن کاملDischarge profiles of ventral tegmental area GABA neurons during movement, anesthesia, and the sleep-wake cycle.
Although mesolimbic dopamine (DA) transmission has been implicated in behavioral and cortical arousal, DA neurons in the ventral tegmental area (VTA) and substantia nigra pars compacta (SNc) are not significantly modulated by anesthetics or the sleep-wake cycle. However, VTA and SN non-DA neurons evince increased firing rates during active wakefulness (AW) and rapid eye movement (REM) sleep, re...
متن کاملNeurotensin inhibits both dopamine and GABA mediated inhibition of ventral tegmental 1 area dopamine neurons
26 Dopamine is an essential neurotransmitter that plays an important role in a number of 27 different physiological processes and disorders. There is substantial evidence that the 28 neuropeptide neurotensin interacts with the mesolimbic dopamine system and can regulate 29 dopamine neuron activity. In these studies we have used whole-cell patch clamp 30 electrophysiology in brain slices from mi...
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ژورنال
عنوان ژورنال: Psychopharmacology
سال: 2013
ISSN: 0033-3158,1432-2072
DOI: 10.1007/s00213-013-3002-3